This is the only optimised whole-cell patch clamp amplifier that fully compensates for series resistance (Rs) and eliminates series resistance errors (US patent 6,700,427).
The VE-2 features the Rs Compensator, a unique circuit that brings complete (100%) series resistance compensation to a conventional patch clamp. In contrast, standard Rs compensation results in oscillation when set above ~90%. Consequently, other amplifiers always leave some uncompensated series resistance with a voltage error.
- Voltage clamp large and fast ionic current, while maintaining voltage clamp control.
- Plot accurate IV curves, without shifts or distortions due to uncompensated Rs.
- Maintain stable Rs compensation even as the pipette resistance shifts during the experimental procedure. (Traditional amplifiers will oscillate if the access resistance decreases during a procedure.)