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Whole-Cell Patch Clamp Amplifier

VE-2 (Alembic Instruments Inc.)
VE-2 amplifier
VE-2 amplifier

This is the only optimised whole-cell patch clamp amplifier that fully compensates for series resistance (Rs) and eliminates series resistance errors (US patent 6,700,427).

The VE-2 features the Rs Compensator, a unique circuit that brings complete (100%) series resistance compensation to a conventional patch clamp. In contrast, standard Rs compensation results in oscillation when set above ~90%. Consequently, other amplifiers always leave some uncompensated series resistance with a voltage error.

- Voltage clamp large and fast ionic current, while maintaining voltage clamp control.

- Plot accurate IV curves, without shifts or distortions due to uncompensated Rs.

- Maintain stable Rs compensation even as the pipette resistance shifts during the experimental procedure. (Traditional amplifiers will oscillate if the access resistance decreases during a procedure.)

 

 

Documents
VE-2 Brochure (1.4 mbs)

Series Resistance Compensation (219 kbs)

Recent Publications (80 kbs)

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